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Table 1 Values of α of the LQ model for survival curves, chromosomal fragments, colour junctions and DNA DSBs of SW-1573 cells after alpha particle irradiation and after γ irradiation

From: Comparison of RBE values of high- LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death

  α-particle irradiation Gy-1 γ-irradiation Gy-1 RBE value
Survival 2.2 ± 0.38 0.15 ± 0.045 14.7 ± 5.1
Chromosomal fragments 16.8 ± 4.5 1.1 ± 0.31 15.3 ± 5.9
Colour junctions 9.2 ± 3.2 0.69 ± 0.2 13.3 ± 6.0
DSB (Gamma-H2AX foci) 25 ± 8.2 25 ± 3.0 1.0 ± 0.3
  1. The chromosomal fragments, colour junctions were determined in chromosome 2 and the α-values are corrected for the DNA content of the complete genome. Survival curves were analyzed using S(D)/S(0) = exp-(αD+βD2) [20, 36, 37]. The values of α for chromosomal fragments colour junctions and DSB are calculated according to F(D) = αD+βD2 [40]