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Table 4 Univariate and multivariate analysis of radiation-induced brain necrosis

From: Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis

Variables Univariate analysis Multivariate analysis
Age 0.2  
Gender 0.3  
KPS 0.04 0.1
Tumor volume <0.0001 0.02
Dose 0.09  
Conformality index 0.04 0.2
Homogeneity index 0.1  
lung histology 0.1  
Melanoma histology 0.3  
Breast histology 0,2  
frontal location 0.2  
parietal location 0.03 0.1
temporal location 0.3  
cerebellar location 0.2  
occipital location 0.3  
brainstem location 0.9  
V10 Gy <0.0001 0.001*
V12 Gy <0.0001 0.001**
V14 Gy <0.0001 0.005°
V16 Gy 0.0001 0.009°°
V18 Gy 0.001 0.05^
  1. *0.003 for symptomatic and 0.04 for asymptomatic brain necrosis
  2. **0.003 for symptomatic and 0.04 for asymptomatic brain necrosis
  3. °0.01 for symptomatic and 0.1 for asymptomatic brain necrosis
  4. °°0.02 for symptomatic and 0.3 for asymptomatic brain necrosis
  5. ^0.03 for symptomatic and 0.5 for asymptomatic brain necrosis