| Univariable Analysis | Multivariable Analysis | ||
---|---|---|---|---|
Characteristics | HR (95% CI) | pvalue | HR (95% CI) | pvalue |
RPA at diagnosis of BM | Â | Â | Â | Â |
   1 | 1 [Reference] |  | 1 [Reference] |  |
   2 | 1.92 (1.30-2.82) | < 0.001 | 1.55 (1.00-2.40) | 0.05 |
   3 | 5.23 (3.50-7.80) | < 0.001 | 4.24 (2.66-6.73) | < 0.001 |
SRS boost at initial BM | Â | Â | Â | Â |
   Yes | 1 [Reference] |  | 1 [Reference] |  |
   No | 3.05 (1.71-5.44) | < 0.001 | 2.94 (1.51-5.73) | 0.002 |
Craniotomy | Â | Â | Â | Â |
   Yes | 1 [Reference] |  | 1 [Reference] |  |
   No | 2.87 (2.15-3.84) | < 0.001 | 2.70 (1.89-3.85) | < 0.001 |
Number of lesions | Â | Â | Â | Â |
   1 | 1 [Reference] |  | 1 [Reference] |  |
   2-3 | 1.31 (0.91-1.89) | 0.139 | 1.19 (0.82-1.72) | 0.36 |
   > 3 | 2.18 (1.66-2.88) | < 0.001 | 1.02 (0.78-1.34) | 0.88 |
HER2 status | Â | Â | Â | Â |
   Positive | 1 [Reference] |  | 1 [Reference] |  |
   Negative and Equivocal | 1.74 (1.39-2.18) | < 0.001 | 1.55 (1.09-2.20) | 0.015 |
Chemotherapy at BM | Â | Â | Â | Â |
   Yes | 1 [Reference] |  | 1 [Reference] |  |
   No | 2.26 (1.81-2.84) | < 0.001 | 1.81 (1.41-2.33) | < 0.001 |
Hormonal therapy at BM | Â | Â | Â | Â |
   Yes | 1 [Reference] |  | 1 [Reference] |  |
   No | 1.64 | < 0.001 | 2.22 (1.66-2.97) | < 0.001 |
Trastuzumab at initial BM | Â | Â | Â | Â |
   Yes | 1 [Reference] |  | 1 [Reference] |  |
   No | 1.74 (1.37-2.20) | < 0.001 | 1.37 (0.94-2.01) | 0.100 |