Table 4 Secondary cancer risk after radiotherapy for breast cancer
Authors, journal, year | No. of patients | Follow up time | organs | Risk for secondary cancer |
|---|---|---|---|---|
Berrington de Gonzalez Br J Cancer (2010) [22] | 182,057 69,181 treated with radiotherapy | 13 years | Lung, oesophagus, pleura, bone and soft tissue Contralateral breast | RR = 1·38 (95% CI 1·26-1·51) RR = 1.09 (95% CI 1.04-1.15) |
Kirova Int J Radiat Oncol Biol Phys (2007) [53] | 16,705 13,472 treated with radiotherapy | 10 years | Lung Contralateral breast | RR = 3.09 (95% CI 1.12-8.53) RR = 1.1 (95% CI 0.96-1.27) |
Roychoudhuri Br J Cancer (2004) [54] | 64,782 33,763 received radiotherapy | > 10 years | Lung | RR = 1.65 (95% CI 1.05-2.54) |
Zablotska Cancer (2003) [31] | 260,541 76,467 treated with radiotherapy | 10 years | lung | 0.30% RR = 2.06 (95% CI 1.53-2.78) |
Prochazka Eur J Cancer (2002) [55] | 141,053 141,053 treated with radiotherapy | > 10 years | lung | RR = 2.3 (95% CI 1.97-2.63) |
Fowble Int J Radiat Oncol Biol Phys (2001) [28] | 1,253 977 treated with radiotherapy | 10 years | Contralateral breast | 7% |
Obedian J Clin Oncol (2000) [29] | 2,416 1,029 treated with radiotherapy | 15 years | Contralateral breast | 10% |