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Table 4 Secondary cancer risk after radiotherapy for breast cancer

From: Can the risk of secondary cancer induction after breast conserving therapy be reduced using intraoperative radiotherapy (IORT) with low-energy x-rays?

Authors, journal, year No. of patients Follow up time organs Risk for secondary cancer
Berrington de Gonzalez
Br J Cancer
(2010) [22]
182,057
69,181 treated with radiotherapy
13 years Lung, oesophagus, pleura, bone and soft tissue
Contralateral breast
RR = 1·38 (95% CI 1·26-1·51)
RR = 1.09 (95% CI 1.04-1.15)
Kirova
Int J Radiat Oncol Biol Phys
(2007) [53]
16,705
13,472 treated with radiotherapy
10 years Lung
Contralateral breast
RR = 3.09 (95% CI 1.12-8.53)
RR = 1.1 (95% CI 0.96-1.27)
Roychoudhuri
Br J Cancer
(2004) [54]
64,782
33,763 received radiotherapy
> 10 years Lung RR = 1.65 (95% CI 1.05-2.54)
Zablotska
Cancer
(2003) [31]
260,541
76,467 treated with radiotherapy
10 years lung 0.30%
RR = 2.06 (95% CI 1.53-2.78)
Prochazka
Eur J Cancer
(2002) [55]
141,053
141,053 treated with radiotherapy
> 10 years lung RR = 2.3 (95% CI 1.97-2.63)
Fowble
Int J Radiat Oncol Biol Phys
(2001) [28]
1,253
977 treated with radiotherapy
10 years Contralateral breast 7%
Obedian
J Clin Oncol
(2000) [29]
2,416
1,029 treated with radiotherapy
15 years Contralateral breast 10%