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Table 2 Summary of results of recent series on stereotactic radiosurgery for GH-secreting pituitary adenomas

From: Radiation techniques for acromegaly

Authors patients type of total dose follow-up tumor biochemical remission late toxicity (%)
   SRS (Gy) median (months) control (%) (%) visual hypopituitarism
Attanasio et al., 2003 [34] 30 GK SRS 20 46 100 30 at 5 years 0 6.7
Jane et al., 2003 [35] 64 GK SRS 15 > 18 NA 36 0 28
Castinetti et al., 2005 [36] 82 GK SRS 26 49.5* NA 17 1.2 17
Gutt et al., 2005 [37] 44 GK SRS 23 22 100 48 NA NA
Kobayashi et al., 2005 [38] 67 GK SRS 18,9 63 100 17 11 15
Jezkova et al., 2006 [39] 96 GK SRS 32 53.7 100 44 at 5 years 0 27.1
Voges et al., 2006 [40] 64 LINAC SRS 16,5 54.3 97 14 and 33 at 3 and 5 years 1.4 13 and 18 at 3 and 5 years
Petit et al., 2007 [32] 22 PSRS 20 GyE 75.6 100 59 0 38
Pollock et al., 2007 [41] 46 GK SRS 20 63 100 11 and 60 at 2 and 5 years 0 33 at 5 years
Vik-Mo et al., 2007 [42] 53 GK SRS 26.5 67 100 58 and 86 at 5 and 10 years 3.8 10 at 5 years
Jagannathan et al., 2008 [43] 95 GK SRS 22 57 98 53 4 34
Losa et al., 2008 [44] 83 GK SRS 21,5 69 97 52 and 85 at 5 and 10 years 0 10 at 10 years
Ronchi et al., 2009 [45] 35 GK SRS 20 114 100 46 at 10 years 0 50
Wan et al., 2009 [46] 103 GK SRS 21,4 67 95 37 0 6
Hayashi et al., 2010 [47] 25 GK SRS 25.2 36 100 40 0 0
Iwai et al., 2010 [48] 26 GK SRS 20 84 96 17 and 47 at 5 and 10 years 0 8
  1. *mean follow-up; NA not assessed.
  2. SRS, stereotactic radiosurgery; GKS, Gamma Knife radiosurgery.
  3. PSRS; proton stereotactic radiosurgery.