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Table 4 Comparison between the current study and Intergroup-0116

From: Postoperative chemoradiation for resected gastric cancer - is the Macdonald Regimen Tolerable? a retrospective multi-institutional study

  Current study INT-0116
  Patient population
Median age, yrs 63 60
Male, % 60 72
T3-T4, % 77 68
N+, % 85 85
  Toxicity
Most common toxicities Hem. + GI Hem. + GI
Grade 3 toxicity 35% 41%
Grade 4 toxicity 22% 32%
Hospitalizations 32% NA
Toxic deaths 1.8% 1%
Discontinuation due to toxicity 36% 31%
  efficacy 1
3-year-DFS 60% 48%
3-year-OS 61% 50%
Proportion of distant relapses 2 60% 65%
  1. Hem. = hematological, GI = gastrointestinal, DFS = disease free survival, OS = overall survival.
  2. 1Efficacy data from the current study is limited only to patients undergoing R0 resection.
  3. 2Proportion of distant relapses out of all relapses, including those combined with locoregional relapses.