Postoperative chemoradiation for resected gastric cancer - is the Macdonald Regimen Tolerable? a retrospective multi-institutional study

Table 4 Comparison between the current study and Intergroup-0116

	Current study	INT-0116
	Patient population
Median age, yrs	63	60
Male, %	60	72
T3-T4, %	77	68
N+, %	85	85
	Toxicity
Most common toxicities	Hem. + GI	Hem. + GI
Grade 3 toxicity	35%	41%
Grade 4 toxicity	22%	32%
Hospitalizations	32%	NA
Toxic deaths	1.8%	1%
Discontinuation due to toxicity	36%	31%
	efficacy ¹
3-year-DFS	60%	48%
3-year-OS	61%	50%
Proportion of distant relapses ²	60%	65%

Hem. = hematological, GI = gastrointestinal, DFS = disease free survival, OS = overall survival.
¹Efficacy data from the current study is limited only to patients undergoing R0 resection.
²Proportion of distant relapses out of all relapses, including those combined with locoregional relapses.

ISSN: 1748-717X