Figure 3

Survival of sarcoma cells after Radiation +/- SAHA Treatment at LD ₂₀ . Survival of KHOS-24OS and A-204 cells treated with different doses of radiation given alone. (open symbols) or in combination with the LD₂₀ of SAHA for each cell line (closed symbols). The data are mean values (and standard deviations) from three independent determinations for each treatment modality. The survival data after combined treatment are normalized to SAHA toxicity alone. The curves represent fits of the linear-quadratic survival expression to the respective data. The slashed lines show the calculated expectation for each modality revealing a supra-additive effect in the real measurements (solid lines).