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Table 3 Relationship between G4-5 RP and pre-SBRT factors

From: Prescreening based on the presence of CT-scan abnormalities and biomarkers (KL-6 and SP-D) may reduce severe radiation pneumonitis after stereotactic radiotherapy

Pre-SBRT factors G4-5 RP G0-3 RP Total X2 test 1-year cumulative incidence of G4-5 RP log-rank
Serum KL-6       
high value 6 17 23 p = 0.0002 32% p < 0.0001
within normal level 2 78 80   3%  
not available 1 13 14    
Serum SP-D       
high value 5 14 19 p = 0.0002 29% p = 0.0001
within normal level 2 79 81   3%  
not available 2 15 17    
IP shadow in CT       
(+) 7 6 13 p < 0.0001 57% p < 0.0001
(-) 2 102 104   2%