Choline PET based dose-painting in prostate cancer - Modelling of dose effects

Radiation Oncology

Table 6 TCP-increase for different sensitivities of choline PET, high whole prostate dose, different α/β values, calculated α and high γ50(ASTRO definition)

α [Gy^-1]	α/β [Gy]	γ50	Det. rate PET [%]	Dose [Gy]	SIB [Gy]	Single dose [Gy]	TCP_conv [%]	TCP Increase [%]
0.04	1.5	2.2	81	78	90	2	77.2	14.9
0.04	1.5	2.2	64	78	90	2	77.2	11.5
0.06	3.1	2.2	81	78	90	2	77.2	14.1
0.06	3.1	2.2	64	78	90	2	77.2	11.0
0.08	8.3	2.2	81	78	90	2	77.2	13.1
0.08	8.3	2.2	64	78	90	2	77.2	10.1

Calculation of the TCP-increase after boosting choline PET positive regions within the prostate up to 90 Gy, higher homogeneous whole prostate dose. α/β was analytically determined in order to achieve agreement between calculated TCD50 and TCD50 obtained by Cheung et al. γ50 was again taken from Cheung's data (ASTRO definition).

ISSN: 1748-717X