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Table 6 TCP-increase for different sensitivities of choline PET, high whole prostate dose, different α/β values, calculated α and high γ50(ASTRO definition)

From: Choline PET based dose-painting in prostate cancer - Modelling of dose effects

α [Gy-1] α/β [Gy] γ50 Det. rate PET [%] Dose [Gy] SIB [Gy] Single dose [Gy] TCPconv [%] TCP Increase [%]
0.04 1.5 2.2 81 78 90 2 77.2 14.9
0.04 1.5 2.2 64 78 90 2 77.2 11.5
0.06 3.1 2.2 81 78 90 2 77.2 14.1
0.06 3.1 2.2 64 78 90 2 77.2 11.0
0.08 8.3 2.2 81 78 90 2 77.2 13.1
0.08 8.3 2.2 64 78 90 2 77.2 10.1
  1. Calculation of the TCP-increase after boosting choline PET positive regions within the prostate up to 90 Gy, higher homogeneous whole prostate dose. α/β was analytically determined in order to achieve agreement between calculated TCD50 and TCD50 obtained by Cheung et al. γ50 was again taken from Cheung's data (ASTRO definition).