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Table 3 Univariate and multivariate analyses for local recurrence-free survival (LRFS) with clinicopathological prognostic factors in patients with cervical cancer following radiotherapy

From: Carbonic anhydrase XII expression is associated with histologic grade of cervical cancer and superior radiotherapy outcome

 

Univariate

Multivariate

Clinicopathological factors

HR (95% CI)

p value*

HR (95% CI)

p value*

Age (> 40 years vs.≤ 40 years)

0.44(0.17-1.13)

0.09

0.41(0.14-1.24)

0.12

CA12 (Positive vs. Negative)

0.37(0.136-1.01))

0.05

0.30(0.09-1.00)

0.05

Histologic type (AD vs. SCC)

3.44(1.26-9.41)

0.02

2.31(0.65-8.19)

0.19

Tumor size (1 unit increase)

1.47(1.12-1.94)

0.01

1.61(1.09-2.36)

0.02

Histologic grade (MD vs. WD)

3.12(0.40-24.42)

0.28

2.37(0.29-19.07)

0.42

Histologic grade (PD vs. WD)

11.56(1.47-90.37)

0.02

7.15(0.85-59.99)

0.07

FIGO stage (IIIA-IVA vs. I~IIB)

3.37(1.35-8.37)

0.01

3.43(1.22-9.61)

0.02

FIGO stage IVB vs. I~IIB)

2.45(0.54-11.09)

0.24

0.75(0.12-4.67)

0.76

  1. SCC: Squamous cell carcinoma; AD: Adenocarcinoma and Adenosquamous carcinoma; WD: well differentiated; MD: moderately differentiated; PD: poorly differentiated; HR: hazard ratio; CI: confidence interval
  2. * p-value from the Cox regression