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Table 5 Calculation of biological effective doses (BED) for the rectal tumor (α/β = 10 Gy) and late normal tissue toxicity (α/β = 3 Gy)

From: Prospective phase II study of preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy - Long-term results

 

29 Gy (10 × 2.9 Gy)

25 Gy (5 × 5 Gy)

45 Gy (25 × 1.8 Gy)

50.4 Gy (28 × 1.8 Gy)

Tumor OTT (α/β = 10 Gy)

37.4

37.5

37.5

42.1

Tumor (α/β = 10 Gy)

37.4

37.5

53.1

59.5

Normal tissue (α/β = 3 Gy)

57.0

66.7

72.0

80.6

  1. Overall treatment time (OTT) was considered (first row) or not (second row) at calculation of BED doses to the tumor.