Radiotherapy and radiosurgery for benign skull base meningiomas

Radiation Oncology

Table 2 Summary of results on main published studies on the FSRT, IMRT, and proton radiotherapy of skull base meningiomas

Authors	Technique	Patients (n)	S + SCRT (%)	SCRT (%)	Volume (ml)	Dose (Gy)	Follow-up (months)	Control rate (%)	Late toxicity (%)
Debus et al., 2001	FSRT	189	69	31	52.5	56.8	35	97 at 5 and 96 at 10 years	12
Jalali et al., 2002	FSRT	41*	63	37	17.9	55	21	100	12.1
Lo et al., 2002	FSRT	18*	60	40	8.8	54	30.5	93.3	5
Torres et al., 2003	FSRT	77*	65	35	16.1	48.4	24	97.2	5.2
Selch et al., 2004	FSRT	45	64	36	14.5	56	36	100 at 3 years	0
Metellus et al., 2005	FSRT	38	20	18	12.7	53	88.6	94.7	2.6
Milker-Zabel et al., 2005	FSRT	317*	67	43	33.6	57.6	67	90.5 at 5 and 89 at 10 years	8.2
Henzel et al., 2006	FSRT	84	60	40	11.1	56	30	100	NA
Brell et al., 2006	FSRT	30	57	43	11.3	52	50	93 at 4 years	6.6
Hamm et al., 2008	FSRT	183*	70	30	27.4	56	36	97 at 5 years	8.2
Uy et al., 2002	IMRT	40*	62.5	27.5	20.2	50.4	30	93 at 5 years	5
Pirzkall et al., 2003	IMRT	20	80	20	108	57	36	100	0
Saja et al., 2005	IMRT	35*	54	46	NA	50.4	19.1	97 at 3 years	0
Milker-Zabel et al., 2007	IMRT	94**	72	28	81.4	57.6	52	93.6	4
Wenkel et al, 2000	Ph + protons	46*	83	17	76	59	53	100 at 5 and 88 at 10 years	16
Vernimmen et al, 2001	protons	23*	65	35	23.3°	20,6*	38°	87	13
Weber et al., 2004	protons	16*	81	19	17.5	56	34.1	91.7 at 3 years	24
Noel et al, 2005	Ph + protons	51*	86	14	17	60.6	21	98 at 4 years	4

S, surgery; FSRT, stereotactic conformal radiotherapy; IMRT, intensive modulated radiotherapy; Ph, photons
*series includes some intracranial meningiomas
**series includes some atypical/malignant meningiomas
° mean

ISSN: 1748-717X