Table 5 Impact of patient-related and dose-volume-related factors on symptoms/problems in multivariate analysis
| Â | factor | time A | time B | time C | time D |
|---|---|---|---|---|---|
| Â | Â | HR [95%CI]/p-value/incidence with presence vs. absence of factor | |||
painful bowel movements ≥rarely | R70≥25% | - | - | - | 0.4 [0.2-0.9] p = 0.03 27% vs. 45% |
| Â | haemorrhoids | 4.5 [1.6-12] p < 0.01 53% vs. 20% | 6.3 [1.3-30] p = 0.02 77% vs. 43% | 2.7 [1.0-7.4] p = 0.05 59% vs. 34% | - |
| Â | chronic renal failure | - | - | - | 7.2 [1.4-36] p = 0.02 75% vs. 29% |
bloody stools ≥rarely | PTV≥300 cm3 | - | - | - | 8.2 [2.4-28] p < 0.01 17% vs. 4% |
|  | R70≥25% | - | - | - | 0.2 [0.1-0.6] p < 0.01 11% vs. 23% |
| Â | haemorrhoids | - | - | 3.5 [1.0-12] p < 0.05 24% vs. 8% | 4.0 [1.2-13] p = 0.02 29% vs. 12% |
| Â | stroke in past history | - | - | - | 7.2 [2.0-26] p < 0.01 42% vs. 12% |
moderate/big problem from: | Â | Â | Â | Â | Â |
bowel habits overall | R70≥25% | - | 0.4 [0.2-0.9] p = 0.03 26% vs. 52% | 0.4 [0.2-1.0] p < 0.05 15% vs. 32% | - |
| Â | haemorrhoids | 8.1 [2.5-26] p < 0.01 29% vs. 5% | 3.4 [1.0-11] p < 0.05 62% vs. 28% | 5.9 [2.1-17] p < 0.01 53% vs. 15% | 3.3 [1.1-10] p = 0.04 29% vs. 12% |
| Â | chronic renal failure | - | - | - | 7.9 [1.9-33] p < 0.01 50% vs. 12% |
rectal urgency | R70≥25% | - | - | 0.3 [0.1-0.6] p < 0.01 13% vs. 35% | - |
| Â | NHT | 4.3 [1.5-12] p < 0.01 11% vs. 3% | - | - | - |
| Â | haemorrhoids | 5.2 [1.5-12] p = 0.03 18% vs. 5% | 3.7 [1.2-12] p = 0.03 62% vs. 30% | - | 3.4 [1.1-10] p = 0.03 29% vs. 12% |
| Â | chronic renal failure | - | - | - | 4.9 [1.1-22] p = 0.04 28% vs. 12% |
losing control of stools | age≥70 years | - | - | 3.6 [1.0-12] p < 0.05 11% vs. 3% | - |
bloody stools | haemorrhoids | - | - | - | 7.0 [1.2-39] p = 0.03 12% vs. 2% |