Table 1 Comparison of the prognostic scores published since 1997, empty fields indicate that a parameter is not used in the index
From: Prognostic indices for brain metastases – usefulness and challenges
Score | Performance status | Age | Extracranial metastases | Controlled primary | Steroid treatment | Number of BM | Volume of BM | Interval to BM | Class I | Class II | Class III | Class IV |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
RPA11 Derived from 3 prospective RTOG studies, n = 1,200 | KPS ≥ 70 vs <70 | <65 years | no vs yes | no vs yes | all 4 favourable factors | other patients | KPS <70 | none | ||||
Rotterdam36 Single institution, n = 1,292 | ECOG 0–1 vs 2–3 | limited activity vs | systemic extensive* | good, moderate or little response | ECOG 0–1 with no or limited systemic tumor activity and good response to steroids | other patients | ECOG2-3 with limited or extensive systemic activity and little response to steroids | none | ||||
SIR37 Single institution, n = 65 | KPS 80–100:2 points KPS 60–70: 1 point KPS ≤ 50: 0 points | ≤ 50: 2 points 51–59: 1 point ≥ 60: 0 points | no evidence of systemic disease or complete remission: 2 points partial remission or stable | disease: 1 point progressive disease: 0 points | 1: 2 points 2: 1 point ≥ 3: 0 points | largest lesion volume <5 cc: 2 points 5–13 cc: 1 point >13 cc: 0 points | 8–10 points | 4–7 points | 1–3 points | none | ||
BSBM43 Single institution, n = 110 | KPS 80–100: 1 point KPS ≤ 70: 0 point | no: 1 point yes: 0 points | yes: 1 point no: 0 points | 3 points | 2 points | 1 point | 0 points | |||||
GPA44 Derived from 5 prospective RTOG studies, n = 1,960 | KPS 90–100: 1 point KPS 70–80: 0.5 points KPS <70: 0 points | <50: 1 point 50–59: 0.5 points >60: 0 points | none: 1 point present: 0 points | 1: 1 point 2–3: 0.5 points >3: 0 points | 3.5–4 points | 3 points | 1.5–2.5 points | 0–1 points | ||||
Rades et al.45 Multi-institutional, n = 1,085 | KPS ≥ 70: 5 points KPS <70: 1 point | ≤ 60: 4 points >60: 3 points | none: 5 points present: 2 points | >8 mo: 4 points ≤ 8 mo: 3 points | 17–18 points | 14–16 points | 11–13 points | 9–10 points |