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Table 4 WBRT vs surgery plus WBRT in randomized trials

From: Neuropsychological testing and biomarkers in the management of brain metastases

Study (ref) Year Treatment (Gy)/number of fractions n Median survival (mo) P Value
Patchell et al [22] 1990 Biopsy + WBRT 36 Gy/12 23 3.4 < 0.01
   S + WBRT   25 9.2  
Vecht et al [23] 1993 WBRT 40Gy/10 31 6 0.04
   S + WBRT   32 10  
Noordijk et al [24] 1994 WBRT 40Gy/10 34 6 0.04
   S + WBRT   32 10  
Mintz et al [25] 1996 WBRT 30Gy/10 43 6.3 0.24
   S + WBRT   41 5.6  
  1. Abbreviatio n: S = Surgery