In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol

Table 1 Summary of the results

	cell line	treatment	results
receptor expression	LNCaP		ER-α + ER-β +
	PC-3		ER-α 0 ER-β 0
clonogenic survival	LNCaP	genistein	survival reduced
		estradiol	survival increased (0.01 μM)/no effect (higher concentrations)
		genistein + RT	area of HRS enlarged
		estradiol + RT	area of HRS enlarged
	PC-3	genistein	survival reduced
		estradiol	survival increased (0.01 μM)/no effect (higher concentrations)
		genistein + RT	HRS abolished
		estradiol + RT	HRS abolished
p21 expression	LNCaP	RT	increased expression
		RT + genistein 10 μM	reduced expression
		RT + estradiol 10 μM	reduced expression
	PC-3		no expression
FACS (cell cycle)	LNCaP	controls	G0/G1 arrest
		genistein or estradiol	G0/G1 arrest
		RT	G0/G1 arrest
	PC-3	genistein or estradiol	no influence
		RT	G2/M arrest
		RT + genistein or estradiol	G2/M arrest reduced

ISSN: 1748-717X