Figure 1

Poorly differentiated neuroendocrine carcinoma – progression and therapy response of disease manifestations. Repeated helical CT scannings were accomplished in the course of the disease relapse (when the patient was referred to our institution), which was defined as day 1. On the basis of the diagnostic description of contrast-enhancing lesions in the transverse view, cross-sectional area (the maximum diameter multiplied by perpendicular bisector) of each lesion was calculated, according to the established World Health Organization criteria for evaluation of tumor response to cytotoxic therapy. Filled circles: lesion size at each CT record, determined relative to the cross-sectional area at first appearance (set to the value of 1). Stars: the radiological review at day 492, done by MRI. Thick lines: duration of the therapy regimens. Arrowheads: time for start of chemotherapy cycles. EP: chemotherapy consisting of etoposide and cisplatin. tem: chemotherapy consisting of temozolomide. RT: radiotherapy. TV1: target volume 1 (pathologic retroperitoneal lymph nodes). TV2: target volume 2 (macroscopic pelvic tumor). TV3: target volume 3 (pathologic supraclavicular lymph nodes).