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Table 3 Estimated excess relative risk (ERR*) of secondary breast and lung cancer 20 years after radiation exposure

From: A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer risk

  Female Breast Female Lung Male Lung
  Age at RT (yrs) Age at RT (yrs) Age at RT (yrs)
  20 30 20 30 20 30
35 Gy mantle RT (95% CI †) 4.6 (2.5–13.3) 2.1 (1.07–6.1) 18.4 (7.0–56.3) 7.6 (3.0–21.8) 12.6 (5.3–26.4) 5.2 (2.3–10.1)
35 Gy IFRT (95% CI) 1.7 (0.90–4.7) 0.74 (0.38–2.2) 6.1 (2.3–18.8) 2.5 (0.99–7.3) 8.3 (3.5–17.3) 3.4 (1.5–6.6)
20 Gy IFRT (95% CI) 1.06 (0.58–3.0) 0.47 (0.24–1.4) 3.5 (1.3–10.7) 1.4 (0.57–4.1) 4.7 (2.0–9.9) 1.9 (0.86–3.8)
  1. * Excess Relative Risk (ERR) = Relative Risk (RR)-1
  2. † 95% CI = 95% confidence interval
  3. The ERR calculations were performed on three representative patients who had values for the mean female breast dose, mean female lung dose, and mean male lung dose that were closest to the median values of the whole group when treated with 35 Gy mantle field RT.