Figure 7
Cross-Plot Analyses. a) The interplay of kg,t and kg,f on treatment outcome, with and without growth of tumor cells in the fluid phase When kg,f is set to 0 (i.e., no growth of cells in the fluid phase), longer treatment breaks are allowed without threatening cure. b) The effect of efficiency factor γ is shown on treatment outcomes. Decreasing the efficiency of transfer of viable cells from one phase to the other (i.e., decreasing γt and/or γf) reduces the number of tumor cells, permitting a longer treatment break. c) The effect of independently varying γf and γt on treatment outcome is shown. High γt and low γf values versus the converse are associated with a higher risk of treatment failure for extended treatment breaks at all kg values. d) The effect of initial number of tumor cells in the brain parenchyma, Nb,t, and radiosensitivity, D0, on treatment outcome is shown. Failure is more likely the higher the value of Nb,t and D0.