Figure 8
From: Radiosensitization of colorectal carcinoma cell lines by histone deacetylase inhibition
SAHA and MS-275 modulate clonogenic regrowth upon cellular exposure to ionizing radiation (IR). The HCT116 cells were exposed to increasing IR doses without (○) or following pre-treatment for 18 hours with SAHA in concentrations of 0.50 μM (■) or 1.0 (M (▲) (upper panel) or MS-275 in concentrations of 1.0 μM (■) or 2.0 μM (▲) (lower panel), to determine relative colony formation compared to the unirradiated situation (mean ± SEM, n = 3–5).