Whole brain radiation therapy in management of brain metastasis: results and prognostic factors

Radiation Oncology

Table 2 univariate analysis of significant factors for survival (Log Rank Test)

Variable	number	%	% OS 12 MONTHS	P
AGE
< 65 YEARS	195	72.3	22.6	0.84
>= 65 YEARS	75	27.7	28
SEX
MALE	111	41.1	23	0.17
FEMALE	159	58.9	25.5
KPS
< 70	154	57	15.4	<0.0001
>= 70	115	42.6	35.2
NEUROSURGERY
YES	41	15.2	49.2	<0.0001
NO	229	84.8	19.2
DOSE(Gy) FRACTIONATION (fr)
40 Gy/20 fr	102	37.8	27.3	0.12
30 Gy/10 fr	134	49.6	24.7
OTHERS	34	12.6
NUMBER LESIONS
SINGLE	103	38.1	33.4	0.009
MULTIPLE	161	59.6	17.9
CHEMOTHERAPY
YES	54	20	36.8	0.09
NO	214	79.2	20.7
RPA CLASS
CLASS I	42	15.5	43.6	<0.0001
CLASS II	72	26.6	30.8
CLASS III	151	55.9	15.3
LOCALIZATION
SUPRATENTORIAL	140	51.9	27	0.29
INFRATENTORIAL	24	8.9	18
BOTH	47	17.4	25.2
PRIMARY DISEASE CONTROL
YES	141	52.2	30.1	0.06
NO	121	44.8	20.2
EXTRA CRANIAL METASTASIS
YES	178	65.9	23.3	0.09
NO	92	34.1	28.6

ISSN: 1748-717X