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Table 3 Univariate analysis of dosimetric parameters associated with radiation-induced liver damage (RILD)

From: Prognostic analysis of radiation-induced liver damage following carbon-ion radiotherapy for hepatocellular carcinoma

Variables

Patients with RILD

Patients without RILD

p-value

PTV (cm3)

  

0.282

  ≥58.9

10

70

 

  <58.9

1

27

 

MLD (Gy(RBE))

  

0.282

  ≥7.1

10

70

 

  <7.1

1

27

 

VS5 (cm3)

  

0.097

  ≥637

5

69

 

  <637

6

28

 

VS10 (cm3)

  

0.048

  ≥506

8

91

 

  <506

3

6

 

VS15 (cm3)

  

0.138

  ≥697

6

75

 

  <697

5

22

 

VS20 (cm3)

  

0.123

  ≥714

6

77

 

  <714

5

20

 

VS30 (cm3)

  

0.036

  ≥739

6

81

 

  <739

5

16

 

VS40 (cm3)

  

0.118

  ≥937

4

60

 

  <937

7

37

 

VS50 (cm3)

   

  ≥968

4

61

 

  <968

7

36

0.110

V5 (%)

  

0.168

  ≥23.5

10

64

 

  <23.5

1

33

 

V10 (%)

  

0.099

  ≥19.7

10

63

 

  <19.7

1

34

 

V15 (%)

  

0.284

  ≥15.0

10

68

 

  <15.0

1

29

 

V20 (%)

  

0.507

  ≥12.9

9

68

 

  <12.9

2

29

 

V30 (%)

   

  ≥13.0

7

50

 

  <13.0

4

47

0.534

V40 (%)

  

0.534

  ≥10.8

7

50

 

  <10.8

4

47

 

V50 (%)

  

0.540

  ≥8.4

7

51

 

  <8.4

4

46

 
  1. PTV planning target volume, MLD mean liver dose, RBE relative biological effectiveness, VSx, normal liver volume spared from less than × Gy (RBE), Vx, percentage of normal liver volume receiving equal to or more than × Gy (RBE)