Real world clinical experience using daily intelligence-assisted online adaptive radiotherapy for head and neck cancer

Table 3 Adaptive versus scheduled target organ at risk comparison over entire course

Organ at risk	Sessions evaluated	Mean total dose difference (Gy) for adapted versus scheduled (CI)	p-value	Change per additional session (p-value)	Interaction between session and group (p-value)
Left Parotid Mean	750	1.40 Gy (− 6.65 Gy to 3.85 Gy)	0.632	0.753	0.666
Right Parotid Mean	750	0.35 Gy (− 1.05 Gy to 0.18 Gy)	0.148	0.040	0.009
Spine dmax	453	1.16 Gy (0.49 Gy to 1.75 Gy)	0.001	0.231	0.095
Brainstem dmax	347	3.85 Gy (2.80 Gy to 4.90 Gy)	< 0.001	0.761	0.695
Mandible dmax	662	− 2.10 Gy (− 3.50 Gy to − 0.70 Gy)	0.001	< 0.001	0.004
Oral Cavity Mean	695	0.11 Gy (− 0.35 Gy to 0.70 Gy)	0.602	0.022	0.004
Esophagus Mean	585	− 2.10 Gy (− 3.15 Gy Gy to − 1.40 Gy)	< 0.001	0.297	0.360
Left Submandibular Mean	524	1.40 Gy (0.7 Gy to 2.10 Gy)	< 0.001	0.469	0.882
Right Submandibular mean	454	0.35 Gy (− 0.02 Gy to 0.70 Gy)	0.175	0.175	0.021
Pharyngeal Constrictors mean	647	− 0.04 Gy (− 1.05 Gy to 0.18 Gy)	0.187	0.002	0.083
Optic Nerve Right Dmax	137	2.45 Gy (− 1.40 Gy to 6.30 Gy)	0.178	0.025	0.266
Optic Nerve Left Dmax	67	1.75 Gy (− 2.10 Gy to 5.25 Gy)	0.389	0.025	0.721
Cochlea Right Mean	312	1.40 Gy (0.07 Gy to 2.45 Gy)	0.035	0.008	0.039
Cochlea Left Mean	277	0.70 Gy (− 0.70 Gy to 1.93 Gy)	0.240	0.404	0.751
Larynx Mean	488	0.21 Gy (− 0.70 Gy to 0.35 Gy)	0.449	0.744	0.184
Larynx Dmax	210	0.05 Gy (− 0.70 Gy to 0.70 Gy)	0.896	0.726	0.048

ISSN: 1748-717X