| Phase 1 | Phase 2 |
---|---|---|
Objective | Commissioning | Validation |
Simulation imaging | CT and MRI | CT and MRI |
MR-CT image registration | Rigid registration based on bone anatomy | Rigid registration based on bone anatomy |
Delineation | Bones, Body and Brain on CT. Target and OARs on MRI | Bones, Body and Brain on sCT. Target and OARs on MRI |
Dose optimisation | Performed on CT | Performed on sCT |
Patient position verification | CT-CBCT | sCT-CBCT |
Patient cohort | 112 CNS cancer patients | 30 glioblastoma g.IV patients |