Table 5 Univariate analyses of potential prognostic factors for locoregional control (LRC)
Factors | LRC at 1 year (%) | LRC at 2 years (%) | LRC at 5 years (%) | p-value |
|---|---|---|---|---|
Age | ||||
65–74 years | 74 | 61 | 44 | |
75–84 years | 92 | 85 | 85 | |
≥ 85 years | 100 | 100 | 100 | 0.02 |
Gender | ||||
Female | 83 | 56 | 46 | |
Male | 82 | 77 | 64 | 0.20 |
ECOG score | ||||
0–1 | 80 | 74 | 68 | |
2–3 | 91 | 66 | - | 0.50 |
Charlson Comorbidity Index | ||||
≤ 5 | 84 | 71 | 59 | |
> 5 | 81 | 72 | 64 | 0.90 |
Clinical tumor classification (cT) | ||||
1 | 100 | - | - | |
2 | 90 | 77 | 51 | |
3 | 81 | 73 | 65 | |
4 | 71 | 57 | 57 | 0.90 |
Clinical lymph node classification (cN) | ||||
Nodal negative (N0) | 92 | 75 | 63 | |
Nodal positive (N +) | 80 | 72 | 63 | 0.80 |
Tumor stage (AJCC) | ||||
1–3 | 80 | 72 | 62 | |
4a | 89 | 70 | 56 | 1.00 |
Localization of the primary tumor | ||||
15–32 cm distance from the incisors | 89 | 82 | 70 | |
33 cm distance from the incisors until gastroesophageal junction | 80 | 68 | 59 | 0.50 |
Administration of full-dose RT | ||||
Yes | 75 | 75 | - | |
No | 83 | 72 | 61 | 0.90 |
Cumulative dose of RT (EQD2) | ||||
≤ 50 Gy | 81 | 78 | 69 | |
> 50 Gy | 83 | 66 | 56 | 0.40 |
Administration of non-modified, full-dose chemotherapy | ||||
Yes | 81 | 77 | 55 | |
No | 83 | 69 | 65 | 0.72 |
Treatment concept | ||||
Neoadjuvant CRT followed by surgical resection | 88 | 84 | 73 | |
Definitive RT/CRT | 78 | 64 | 56 | 0.10 |