Table 3 Factors contributing to the development of CKD stage 4–5 in a Cox proportional hazard model, univariable and multivariable analyses
From: Low rate of severe-end-stage kidney disease after SABR for localised primary kidney cancer
Baseline variable | Univariate | Multivariate | ||
|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | |
CKD group | ||||
Group 2 versus group 1 | 13.8 (1.68–113) | 0.015 | 9.7 (1.05–88.8) | 0.045 |
Group 3 versus group 1 | 43.3 (5.52–340) | 0.000 | 31.2 (3.6–268) | 0.002 |
Single versus multi-fraction SABR | 0.22 (0.070–0.69) | 0.009 | 0.51 (0.14–1.8) | 0.30 |
Age (< median vs. ≥ median) | 2.3 (0.91–6.0) | 0.079 | 1.2 (0.45–3.2) | 0.71 |
Tumour size (< 4cm vs. 4 + cm) | 2.2 (0.73–6.8) | 0.16 | Not applicable | – |
Hypertension | 1.4 (0.41–4.9) | 0.58 | Not applicable | – |
Diabetes | 1.3 (0.53–3.3) | 0.56 | Not applicable | – |
Dual versus solitary kidney | 0.7 (0.1–5.1) | 0.7 | Not applicable | – |