Table 2 Schedule for procedures of the ALA-RDT in GBM study

(pre)OP

1. week

2. week

3. week

4. week

Treatment Day

Cohort

Intervention

-3

-2

0

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

20

0

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

1

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

2

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

X

3

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

X

X

4

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

X

X

X

5

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

X

X

X

X

6

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

X

X

X

X

X

7

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

X

X

X

X

X

X

8

RT with 1.8 Gy

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

X

Surgery of rGBM

X

5-ALA before RT (RDT)

X

X

X

X

X

X

X

X