Table 4 Average dose-volume indices and NTCP for planned, non-adapted dose accumulation (non-adapt), and adapted dose accumulation (adapt)

109.09 ± 2.57

108.13 ± 2.15

107.88 ± 2.53

− 0.97 ± 1.45

0.008

− 0.24 ± 1.71

0.533

25.21 ± 15.19

25.69 ± 15.01

24.21 ± 15.63

0.48 ± 1.35

0.131

− 1.47 ± 3.15

0.050

11.74 ± 8.3

12.91 ± 8.38

12.08 ± 8.77

1.17 ± 0.8

0.034

− 0.83 ± 0.9

0.086

8.11 ± 8.3

8.13 ± 8.38

8.37 ± 8.77

0.02 ± 0.8

0.917

0.24 ± 0.9

0.369

36.33 ± 14.25

38.08 ± 14.24

36.66 ± 14.55

1.75 ± 2.3

0.003

− 1.42 ± 2.79

0.035

28.45 ± 16.62

31.71 ± 18.61

29.13 ± 17.23

3.26 ± 3.71

0.004

− 2.58 ± 3.09

0.006

68.94 ± 3.98

68.14 ± 4.03

68.33 ± 3.91

− 0.8 ± 0.54

 < 0.001

0.19 ± 0.97

0.398

16.83 ± 12.72

16.74 ± 12.53

17.04 ± 12.72

− 0.09 ± 1.15

0.727

0.31 ± 1.13

0.24

27.52 ± 12.54

27.78 ± 11.79

27.11 ± 12.58

0.26 ± 4.07

0.775

− 0.67 ± 4.13

0.476

24.08 ± 11.39

24.89 ± 10.99

24.24 ± 11.1

0.82 ± 2.21

0.16

− 0.65 ± 2.28

0.272

46.21 ± 20.96

48.94 ± 21.31

47.83 ± 22.19

2.72 ± 4

0.016

− 1.11 ± 4.08

0.294

16.62 ± 8.45

16.94 ± 8.79

17.21 ± 9.02

0.32 ± 1.06

0.278

0.27 ± 1.56

0.523

34.4 ± 19.37

35 ± 20.28

35.86 ± 20.92

0.6 ± 2.81

0.44

0.87 ± 3.85

0.414

37.42 ± 24.47

37.96 ± 24.18

37.69 ± 24.1

0.54 ± 1.94

0.457

− 0.27 ± 3.47

0.834

35.34 ± 19.01

36.64 ± 19.42

35.1 ± 18.66

1.3 ± 2.35

0.096

− 1.55 ± 2.51

0.068

36.48 ± 6.91

37.78 ± 5.61

36.59 ± 6.94

1.3 ± 1.65

0.11

− 1.2 ± 1.94

0.191

32.09 ± 17.48

31.01 ± 17.8

31.72 ± 17.11

− 1.08 ± 1.66

0.284

0.71 ± 0.87

0.201

14.08 ± 8.13

13.79 ± 6.15

13.44 ± 6.05

− 0.3 ± 2.37

0.818

− 0.35 ± 2.2

0.770

32.77 ± 11.33

33.07 ± 11.59

32.34 ± 11.22

0.3 ± 2.25

0.804

− 0.73 ± 2.48

0.597

21.81 ± 10.86

20.79 ± 9.75

19.48 ± 10.97

− 1.02 ± 1.59

0.289

− 1.31 ± 1.73

0.229

15.59 ± 7.06

15.9 ± 8.11

14.68 ± 6.7

0.32 ± 1.08

0.597

− 1.22 ± 1.78

0.262

95.15 ± 0.47

90.14 ± 7.94

96.3 ± 1.02

− 5.01 ± 7.87

0.011

6.16 ± 7.77

0.002

99.44 ± 1.07

98.46 ± 3.5

99.3 ± 1.19

− 0.98 ± 3.28

0.198

0.84 ± 3.23

0.257

96.34 ± 2.25

92.31 ± 5.92

97.26 ± 1.51

− 4.03 ± 5.46

0.016

4.95 ± 5.87

0.008

99.47 ± 0.62

98.86 ± 0.79

99.41 ± 0.59

− 0.61 ± 0.41

 < 0.001

0.56 ± 0.38

 < 0.001

96.33 ± 2.32

87.68 ± 8.13

96.96 ± 1.4

− 8.65 ± 6.99

0.001

9.28 ± 7.64

0.001

99.42 ± 0.43

96.71 ± 3.18

99.2 ± 0.51

− 2.71 ± 3.08

0.006

2.49 ± 3.06

0.009

6.69 ± 6.23

8.68 ± 8.94

7.28 ± 7.19

1.99 ± 3.66

0.025

− 1.4 ± 3.55

0.093

16.26 ± 21.41

26.05 ± 33.95

18.53 ± 24.3

9.79 ± 15.75

0.021

− 7.52 ± 13.59

0.037

19.53 ± 20.46

20.63 ± 20.28

20.06 ± 20.02

1.1 ± 3.49

0.228

− 0.56 ± 3.22

0.495

7.37 ± 8.18

7.69 ± 8.54

8 ± 9.4

0.32 ± 1

0.171

0.31 ± 1.57

0.387

22.48 ± 17.32

24.42 ± 17.49

23.1 ± 17.57

1.94 ± 2.46

0.061

− 1.31 ± 2.9

0.241