Table 3 Average difference of dose-volume indices between dose calculated on rCT_def, pCT, and sCT with physician-corrected and uncorrected contours (range is reported in brackets)

Dmax (%), n = 13

0.16 ± 1.59

− 0.05 ± 1.41

0.02 ± 1.42

(− 3.16, 2.47)

(− 2.41, 3.7)

(− 2.5, 3.71)

Brainstem Dmax (%), n = 13

4.03 ± 5.19

0.74 ± 5.23

0.94 ± 3.98

(− 2.99, 14.36)

(− 7.61, 12.49)

(− 5.23, 11.47)

Cochlea_ips Dmean (%), n = 13

3.32 ± 4.45

0.93 ± 3.42

0.92 ± 2.83

(− 2.91, 12.85)

(− 5.45, 6.51)

(− 3.28, 7.53)

Cochlea_con Dmean (%), n = 9

1.49 ± 2.21

− 0.05 ± 2.99

0.16 ± 0.98

(− 0.09, 6.27)

(− 4.95, 6.63)

(− 1.59, 2.28)

Constrictors Dmean (%), n = 13

3.97 ± 7.31

− 0.33 ± 2.9

0.06 ± 1.22

(− 11.49, 14.28)

(− 4.85, 4.42)

(− 2.37, 2.19)

Larynx Dmean (%), n = 12

3.31 ± 5.29

0.49 ± 2.25

0.24 ± 1.02

(− 3.2, 14.85)

(− 2.71, 4.66)

(− 0.9, 2.18)

Mandible Dmax (%), n = 13

0.38 ± 1.95

− 0.47 ± 1.66

− 0.25 ± 1.24

(− 2.56, 3.76)

(− 2.78, 2.59)

(− 2.23, 2.07)

Oral Cavity Dmean (%), n = 13

− 0.27 ± 2.83

− 0.06 ± 1.1

0.14 ± 0.58

(− 6.17, 3.07)

(− 3.11, 1.64)

(− 0.8, 1.57)

Spinal Cord Dmax (%), n = 13

4.41 ± 9.38

0.68 ± 2.65

1.12 ± 2.92

(− 22.21, 13.99)

(− 2.72, 6.48)

(− 2.73, 9.32)

Parotid_ips Dmean (%), n = 8

− 0.29 ± 9.1

0.18 ± 3.52

0.39 ± 0.7

(− 18.67, 8.57)

(− 5.88, 4.44)

(− 0.12, 1.82)

Parotid_ips V20Gy (%), n = 8

0.75 ± 12.18

0.77 ± 5.35

1.17 ± 2.27

(− 21.74, 18.85)

(− 9.17, 7.31)

(− 0.16, 6.26)

Parotid_con Dmean (%), n = 10

1.11 ± 1.67

0.24 ± 1.24

0.13 ± 0.46

(− 0.21, 4.87)

(− 2.46, 2.22)

(− 0.65, 0.95)

Parotid_con V20Gy (%), n = 10

3.95 ± 3.02

− 0.08 ± 2.75

− 0.31 ± 1.3

(− 0.07, 6.79)

(− 4.7, 2.52)

(− 2.12, 1.51)

Submand_ips Dmean (%), n = 11

3.75 ± 7.16

0.65 ± 2.74

− 0.3 ± 0.79

(− 7.55, 17.71)

(− 3.43, 6.57)

(− 1.51, 0.81)

Submand_con Dmean (%), n = 10

0.09 ± 2.12

− 0.03 ± 0.57

0.03 ± 0.43

(− 3.26, 4.85)

(− 1.21, 0.72)

(− 0.81, 0.7)

Esophagus Dmean (%), n = 4

1.83 ± 3.78

− 0.05 ± 1.06

− 0.34 ± 1.11

(− 3.76, 4.26)

(− 1.38, 1.2)

(− 1.38, 1.13)

Eye_ips Dmax (%), n = 4

− 1.2 ± 3.03

− 1.28 ± 0.68

− 1.53 ± 2.26

(− 5.08, 2.17)

(− 2.04, − 0.42)

(− 4.92, − 0.36)

Eye_con Dmax (%), n = 4

− 0.24 ± 4.1

1.97 ± 1.65

0.18 ± 0.47

(− 5.81, 3.78)

(− 0.35, 3.31)

(− 0.32, 0.82)

ON_ips Dmax (%), n = 4

2.37 ± 13.22

2.3 ± 10.02

− 0.75 ± 1.56

(− 10.28, 19.24)

(− 5.89, 16.67)

(− 3.09, 0.23)

ON_cont Dmax (%), n = 4

− 1.59 ± 9.91

5.21 ± 9.56

0.7 ± 2.17

(− 10.17, 8.74)

(− 3.05, 18.57)

(− 0.79, 3.92)

Optic Chiasm Dmax (%), n = 4

6.49 ± 10.28

2.81 ± 5.1

2.91 ± 6.01

(− 3.28, 19.82)

(− 3.73, 8.69)

(− 0.4, 11.92)

CTV_primary V100 (%), n = 13

− 6.37 ± 11.98

− 0.86 ± 2.35

− 0.21 ± 1.18

(− 42.96, 3.57)

(− 5.95, 2.14)

(− 2.72, 1.26)

CTV_primary V95 (%), n = 13

− 2.72 ± 6.62

− 0.69 ± 1.33

− 0.2 ± 0.41

(− 24.32, 0.46)

(− 2.54, 0.41)

(− 1.09, 0.29)

CTV_scondary V100 (%), n = 7

− 4.23 ± 2.96

− 1.18 ± 0.98

− 0.46 ± 0.62

(− 7.09, − 0.56)

(− 2.72, − 0.22)

(− 1.62, 0.18)

CTV_scondary V95 (%), n = 7

− 2.17 ± 1.71

− 0.44 ± 0.56

− 0.25 ± 0.39

(− 4.54, 0.07)

(− 1.17, 0.37)

(− 0.98, 0.14)

CTV_tertiary V100 (%), n = 7

− 11.84 ± 11.64

− 1.52 ± 3.25

− 1.88 ± 2.25

(− 33.5, − 2.25)

(− 3.9, 4.8)

(− 6.2, 0.33)

CTV_tertiary V95 (%), n = 7

− 5.08 ± 4.78

− 0.31 ± 2.47

− 1.09 ± 1.47

(− 14.1, − 0.07)

(− 2.58, 4.24)

(− 3.97, − 0.02)