Table 3 Dosimetric comparison of VMATAuto and VMATClinical for institution A and B (mean ± standard deviation)
| Â | Â | Institution A | Institution B | ||||
|---|---|---|---|---|---|---|---|
Metric | VMATAuto | VMATClinical | p value | VMATAuto | VMATClinical | p value | |
PTV60 | D98% (Gy) | 58.8 ± 0.1 | 59.0 ± 0.2 | 0.00 | 59.0 ± 0.1 | 58.7 ± 0.3 | 0.00 |
|  | D99% (Gy) | 58.7 ± 0.1 | 58.8 ± 0.3 | 0.03 | 58.9 ± 0.1 | 58.5 ± 0.4 | 0.00 |
|  | D2% (Gy) | 61.3 ± 0.1 | 60.8 ± 0.3 | 0.00 | 61.0 ± 0.1 | 60.9 ± 0.4 | 0.68 |
|  | CI | 0.562 ± 0.027 | 0.570 ± 0.041 | 0.31 | 0.601 ± 0.031 | 0.636 ± 0.042 | 0.00 |
|  | HI | 0.041 ± 0.002 | 0.030 ± 0.007 | 0.00 | 0.032 ± 0.002 | 0.037 ± 0.009 | 0.03 |
PTV57.5 | D98% (Gy)* | 55.9 ± 0.1 | 55.5 ± 0.9 | 0.06 | 55.7 ± 0.2 | 54.7 ± 0.2 | 0.00 |
|  | D99% (Gy) | 56.0 ± 0.2 | 55.6 ± 0.9 | 0.07 | 55.9 ± 0.2 | 54.9 ± 0.2 | 0.00 |
|  | D2% (Gy)* | 59.9 ± 0.1 | 60.2 ± 0.4 | 0.02 | 60.3 ± 0.1 | 60.1 ± 0.5 | 0.18 |
|  | CI | 0.827 ± 0.013 | 0.862 ± 0.043 | 0.00 | 0.845 ± 0.013 | 0.863 ± 0.040 | 0.02 |
|  | HI* | 0.068 ± 0.004 | 0.080 ± 0.014 | 0.00 | 0.077 ± 0.004 | 0.093 ± 0.009 | 0.00 |
PTV48 | D98% (Gy)* | 46.5 ± 0.3 | 45.8 ± 0.5 | 0.00 | 46.5 ± 0.2 | 45.5 ± 0.7 | 0.00 |
|  | D99% (Gy) | 47.1 ± 0.7 | 46.5 ± 0.9 | 0.00 | 47.1 ± 0.8 | 46.4 ± 1.0 | 0.00 |
|  | D2% (Gy)* | 57.0 ± 0.4 | 57.3 ± 0.9 | 0.37 | 57.2 ± 0.3 | 56.5 ± 0.9 | 0.01 |
|  | CI | 0.707 ± 0.017 | 0.745 ± 0.033 | 0.00 | 0.698 ± 0.021 | 0.683 ± 0.044 | 0.23 |
|  | HI* | 0.206 ± 0.007 | 0.224 ± 0.015 | 0.00 | 0.211 ± 0.005 | 0.219 ± 0.020 | 0.17 |
Rectum | V24.3Gy (%) | 47.2 ± 13.0 | 62.3 ± 10.4 | 0.00 | 51.9 ± 11.6 | 60.3 ± 10.3 | 0.00 |
|  | V32.4Gy (%) | 32.9 ± 12.1 | 44.1 ± 11.5 | 0.00 | 38.6 ± 10.9 | 43.6 ± 9.9 | 0.00 |
|  | V40.5Gy (%) | 23.0 ± 9.1 | 26.5 ± 8.9 | 0.00 | 28.2 ± 8.8 | 29.7 ± 8.4 | 0.05 |
|  | V48.6Gy (%) | 13.6 ± 4.3 | 14.5 ± 5.3 | 0.17 | 15.9 ± 4.4 | 15.8 ± 5.0 | 0.79 |
|  | V52.7Gy (%) | 9.5 ± 2.8 | 10.4 ± 3.8 | 0.16 | 10.1 ± 3.0 | 10.4 ± 3.9 | 0.50 |
|  | V56.8Gy (%) | 3.9 ± 1.6 | 6.4 ± 2.6 | 0.00 | 4.8 ± 2.0 | 5.5 ± 2.3 | 0.00 |
|  | V60.0Gy (%) | 0.0 ± 0.0 | 0.3 ± 0.4 | 0.00 | 0.0 ± 0.1 | 0.3 ± 0.4 | 0.00 |
|  | DMean (Gy) | 25.3 ± 4.7 | 29.0 ± 4.3 | 0.00 | 28.3 ± 4.1 | 30.1 ± 3.3 | 0.00 |
Bladder | V40.5Gy (%) | 25.3 ± 14.7 | 24.0 ± 14.1 | 0.00 | 15.5 ± 7.4 | 16.4 ± 7.4 | 0.01 |
|  | V48.6Gy (%) | 18.5 ± 11.3 | 17.9 ± 11.1 | 0.02 | 10.7 ± 5.9 | 11.4 ± 5.6 | 0.02 |
|  | V60.0Gy (%) | 1.8 ± 1.6 | 2.3 ± 1.7 | 0.07 | 1.2 ± 0.9 | 1.1 ± 0.8 | 0.65 |
|  | DMean (Gy) | 24.3 ± 9.3 | 23.8 ± 9.2 | 0.20 | 17.4 ± 5.3 | 18.7 ± 5.7 | 0.00 |
Bowel | V40.5Gy (cm3) |  |  |  | 0.8 ± 1.8 | 0.8 ± 1.6 | n < 10 |
Femoral Head (Lt) | V40.5Gy (%) |  |  |  | 0.0 ± 0.0 | 0.0 ± 0.1 | n < 10 |
Femoral Head (Rt) | V40.5Gy (%) |  |  |  | 0.0 ± 0.0 | 0.0 ± 0.0 | n < 10 |
External | D1.8cm3 (Gy) | 61.2 ± 0.1 | 60.8 ± 0.2 | 0.00 | 61.0 ± 0.1 | 61.0 ± 0.4 | 0.88 |
External | V5.0Gy (%) | 34.8 ± 6.1 | 32.5 ± 6.0 | 0.00 | 27.2 ± 2.7 | 27.4 ± 2.8 | 0.17 |
Beam MU | MU | 637 ± 36 | 570 ± 37 | 0.00 | 739 ± 53 | 640 ± 118 | 0.01 |
Plan Ranking vs VMATClinical | Plans Superior (%) | 90% | 65% | ||||
| Â | Plans Equivalent (%) | 0% | 30% (35%) | ||||
| Â | Plans Inferior (%) | 10% | 5% (0%) | ||||