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Table 2 Final planning goals and weighting factors for both institutions

From: Multi-institutional evaluation of a Pareto navigation guided automated radiotherapy planning solution for prostate cancer

Priority 1: Primary Conformality Goals (WF = 1000)

ROI Name

Dose Parameter

Target (Gy)

Distance (cm)

   

PTV48

Dmax

46.8

1.5

   

Priority 2: Target Goals (WF = 250)

ROI Name

Dose Parameter

Target

(%Presc,PTV)

    

PTV60

Dmin

98.7

    

PTV60

Dmax

101.7

    

PTV60

D50% max

99.5

    

PTV57.5

Dmin

98.7

    

PTV57.5

Dmax

102.5

    

PTV48

Dmin

97.3

    

PTV48

Dmax

104.9

    

Priority 3: Trade-off Goals (Standard)

ROI Name

Dose Parameter

Target

(Gy or %Vol)

WF (IA)

WF (IB)

  

Rectum

V23.4 Gy (%)

0.0

3.5

3.5

  

Rectum

V31.5 Gy (%)

0.0

3.5

3.5

  

Rectum

V39.6 Gy (%)

0.0

0.044

-

  

Rectum

V47.7 Gy (%)

0.0

0.088

-

  

Rectum

V51.8 Gy (%)

0.0

29.9

29.9

  

Rectum

V55.9 Gy (%)

0.0

3.5

-

  

Rectum

Dmax (Gy)

60.0

0.586

0.586

  

Rectum

Dmean (Gy)

5.0

5.84

5.84

  

Bladder

V30.0 Gy (%)

0.0

0.316

0.316

  

Bladder

V39.6 Gy (%)

0.0

0.316

0.316

  

Bladder

V47.7 Gy (%)

0.0

0.316

0.316

  

Bladder

V51.8 Gy (%)

0.0

0.316

0.316

  

Bladder

V55.9 Gy (%)

0.0

0.316

-

  

Bladder

Dmax (Gy)

54.0

0.316

0.316

  

Bladder

Dmean (Gy)

5.0

3.73

3.73

  

Bowel

V36.0 Gy (%)

0.0

-

0.413

  

Bowel

V45.6 Gy (%)

0.0

-

0.413

  

Priority 3: Trade-off Goals (Dose Fall Off)

ROI Name

Fall Off Type

High Dose Level (Gy)

Low Dose Level (Gy)

Dose Gradient

(%Presccm− 1)

WF (IA)

WF (IB)

External

Normal Tissue Falloff

60.0

30.0

50%

204

204

PTV57.5

Intra PTV Falloff

54.0

54.0

75%

10.7

29.8

PTV48

Intra PTV Falloff

54.6 (54.0)*

45.6

75%

29.8

29.8

  1. Abbreviations: %Presc, PTV = % of individual PTV prescription dose; %Presc = % of overall treatment prescription; %Vol = % volume of ROI, WF = weighting factor
  2. Notes: Differences between IA and IB AutoPlan protocols are highlighted in bold. WF = ‘-’ indicates the planning goal was removed for the institution specific protocol. Priority 3 targets = 0.0 by default, but can be specified if desired. The target is dynamically adjusted during optimisation and therefore initial values have negligible impact plan quality, but may decrease planning time if correctly defined
  3. *Value outside and inside parenthesis correspond to IA and IB respectively