Fig. 1

Pareto navigation calibration interface. Navigation is performed using the slider bars (top left), with the dose distribution (top centre) and DVH (top right– solid line) updated in real time within RayStation’s evaluation module. During navigation the operator can set the navigated distribution as a reference distribution (bottom centre) and DVH (top right– dotted line) to aid in the decision making. In this example the navigated position represents a solution where the rectum is spared at the expense of homogeneity and conformality (Cal₁) with the reference distribution representative of the final calibration for I_A (Cal₂). The corresponding Cal₂ slider positions are provided for reference (bottom left) and isodose legends have been enhanced for clarity. ROIs: rectum (brown), bladder (yellow), external (blue), PTV60 (pink), PTV57.5 (red) and PTV48 (orange)