Table 1 Characteristics of included studies
Year | Author | Study | Sites | No. of patients | Median Age | % HGG | % Grade 4 | Lymphopenia cutoff | Lymphopenia event definition | Time Classification | Incidence of lymphopenia | Median OS of lymphopenia group | Median Survival of non-lymphopenia group | p-value of OS difference | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 2011 | Grossman | Prospective | Multicenter | 96 | 57 | 100% | 85% | < 200 CD4/cc | At 2-months after start of CRT | time-point | 39.60% | 13.1 | 19.7 | 0.002 |
2 | 2016 | Rahman | Retrospective | Single | 196 | 59 | 100% | 100% | < 500 TLC/cc | Any time from start of CRT to 6 weeks after | time-range | 47% | 14.1 | 18.2 | 0.003 |
3 | 2017 | Turkaj | Retrospective | Single | 127 | 61 | 100% | 100% | NR | Any time from start of CRT to 2.5 months after | time-range | NR | 16.8 | 25.5 | 0.04 |
4 | 2018 | Song | Retrospective | Single | 96 | 61 | 100% | 100% | < 400 TLC/cc | At 1-month after CRT completion | time-point | 13.50% | 8.4 | 18 | 0.041 |
5 | 2019 | Byun | Retrospective | Single | 336 | 58 | 100% | 100% | < 500 TLC/cc | Any time from start of CRT to 3-months after | time-range | 35.10% | 18.2 | 22 | 0.028 |
< 500 TLC/cc | At 3-months after start of CRT | time-point | NR | NR | NR | NR | |||||||||
6 | 2019 | Hui | Retrospective | Single | 319 | 57 | 100% | 100% | < 500 TLC/cc | Any time from start of CRT to 3-months after | time-range | NR | NR | NR | NR |
7 | 2019 | Kim | Retrospective | Single | 219 | 54 | 100% | 100% | < 500 TLC/cc | At 1-month after CRT completion | time-point | 2.90% | 13 | 19.5 | 0.011 |
8 | 2019 | Ye | Retrospective | Single | 148 | 47 | 66.20% | 43.90% | < 1,000 TLC/cc | Any time from start of CRT to end of CRT | time-range | 46.60% | 29 | 61.5 | 0.004 |
9 | 2020 | Ahn | Retrospective | Single | 97 | 59 | 100% | 100% | < 1,000 TLC/cc | At 1-month after CRT completion | time-point | 44% | 14.5 | 21 | 0.017 |
10 | 2020 | Mohan | Prospective | Single | 84 | 53 | 100% | 100% | < 500 TLC/cc | Any time from start of CRT to 1-month after | time-range | 31% | 20.8 | 25.1 | 0.46 |