Hemostatic radiotherapy in clinically significant tumor-related bleeding: excellent palliative results in a retrospective analysis of 77 patients

Table 7 Influence of potential prognostic factors on patients’ OS

Variable (n)	Overall survival
Variable (n)	Hazard ratio (95% CI)	P value univariable	P value multivariable
Age	1.00 (0.98–1.02)	0.97
≥ 70 (41) versus < 70 (36)	0.77 (0.45–1.30)	0.32
Sex
Male (27) versus female (50)	2.26 (1.31–3.90)	< 0.01	n.s
CCI
> 4 (38) versus ≤ 4 (39)	2.02 (1.17–3.45)	0.01	n.s
Dose in Gy
≥ 39 (47) versus < 39 (30)	0.63 (0.37–1.07)	0.09
Transfusion(s) necessary
Yes (30) versus No (47)	1.20 (0.70–2.07)	0.51
Bleeding as first sign of disease
Yes (32) versus No (45)	0.66 (0.38–1.13)	0.13
Systemic therapy
Yes (30) versus No (47)	0.88 (0.51–1.52)	0.64
Acute organ toxicity
Yes (35) versus No (42)	0.69 (0.41–1.19)	0.18
Localization pelvis versus other
Yes (46) versus No (31)	0.54 (0.32–0.93)	0.03	n.s
Therapy completed as intended
No (14) versus Yes (63)	4.27 (2.07–8.78)	< 0.01	< 0.001
Radiotherapy technique^a
Dynamic (17) versus conventional (55)	0.63 (0.33–1.21)	1.66
Primary site
CC/ENC (29) versus others (48)	0.29 (0.16–0.54)	< 0.01	< 0.001

Calculations were done by cox regression analyses. P values < 0.05 were considered statistically significant. Variables with p < 0.1 in univariable analysis were consecutively tested in a multivariable cox regression model
CC carcinoma of the cervic, ENC endometrioid carcinoma, CI confidence interval, CCI Charlson Comorbidity Index, Gy Gray, n.s. not significant
^aNot applicable in n = 6 patients (n = 3 brachytherapy, n = 3 mixed techniques, Table 3)
Statistically significant values (P<0.05) are depicted in bold

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