Hemostatic radiotherapy in clinically significant tumor-related bleeding: excellent palliative results in a retrospective analysis of 77 patients

Table 6 Influence of potential prognostic factors on patients’ bleeding stop

Variable (n)	Symptom relief: clinically determined bleeding stop
Variable (n)	Hazard ratio (95% CI)	P value univariable	P value multivariable
Age	1.03 (0.98–1.08)	0.27
Sex
Male (27) versus female (50)	0.28 (0.06–1.28)	1.01
CCI	0.67 (0.46–0.99)	0.04	n.s
Dose in Gy	1.07 (1.01–1.13)	0.02	n.s
Transfusion(s) necessary
Yes (30) versus No (47)	2.05 (0.39–10.89)	0.40
Bleeding as first sign of disease
Yes (32) versus No (45)	1.21 (0.27–5.45)	0.81
Systemic therapy
Yes (30) versus No (47)	0.88 (0.51–1.52)	0.64
Acute organ toxicity
Yes (35) versus No (42)	0.69 (0.41–1.19)	0.18
Localization pelvis versus other
Yes (46) versus No (31)	2.29 (0.52–10.02)	0.27	n.s
Therapy completed as intended
No (14) versus Yes (63)	0.44 (0.01–0.26)	< 0.01	0.01
Radiotherapy technique^a
Dynamic (17) versus conventional (55)	0.57 (0.12–2.63)	0.47

Calculations were done by logistic regression analyses. P values < 0.05 were considered statistically significant. Variables with p < 0.1 in univariable analysis were consecutively tested in a multivariable logaritmic regression model
CI confidence interval, CCI Charlson Comorbidity Index, Gy Gray, n.s. not significant
^aNot applicable in n = 6 patients (n = 3 brachytherapy, n = 3 mixed techniques, Table 3)
Statistically significant values (P<0.05) are depicted in bold

ISSN: 1748-717X