Table 3 Radiotherapy prior to RID lesion resection

Number of RT courses in the area of RID

 1

17 (50.0%)

14 (77.8%)

3 (18.8%)

 2

15 (44.1%)

4 (22.2%)

11 (68.8%)

 3

2 (5.9%)

0 (0.0%)

2 (12.5%)

Median cumulative EQD2₂ in Gy excluding boost (IQR)

103.2 (60.0–176.3)

60.0 (55.6–70.3)

162.4 (121.8–235.6)

Median cumulative BED₂ in Gy excluding boost (IQR)

206.4 (120.0–352.5)

120.0 (111.3–140.6)

324.8 (243.6–471.3)

Number of cases that received hypofractionation (single dose ≥2.5 Gy) in at least one RT course

20 (58.8%)

4 (22.2%)

16 (100.0%)

Median single RT course EQD2₂ in Gy excluding boost (IQR)

60.0 (55.2–90.0)

60.0 (53.3–60.0)

71.6 (60.0–120.8)

Median number of fractions per single RT course (IQR)

11 (1–30)

30 (29.3–30.8)

3 (1–11)

Fractions per day (single RT course)

 3/week

1 (1.9%)

0 (0.0%)

1 (3.2%)

 1/day

48 (90.6%)

19 (86.4%)

29 (93.5%)

 2/day

4 (7.5%)

3 (13.6%)

1 (3.2%)

Median prescription dose (single RT course) in Gy (IQR)

41.8 (24.0–59.2)

59.4 (53.3–60.0)

25.6 (21.0–41.8)

Median single fraction dose in Gy (IQR)

3.8 (2.0–18.0)

2.0 (1.8–2.0)

8.0 (3.8–21.0)

Median maximum dose within PTV (single RT course) in Gy (IQR)

43.4 (30.0–63.6)

64.1 (56.1–68.3)

30.0 (26.5–43.3)

Median PTV volume in ccm excluding WBRT (IQR)*

15.9 (4.2–196.0)

203.9 (155.1–308.9)

6.7 (3.2–14.2)

Median coverage of RID lesion by single RT course PTV in percent (IQR)

82.1 (42.9–99.8)

97.8 (91.8–100.0)

46.4 (39.2–82.1)

Median coverage of RID lesion by combined PTV in percent (IQR)

97.8 (88.1–100.0)

99.9 (96.7–100.0)

89.8 (52.9–99.7)

Number of RTs with boost

13 (24.5%)

12 (54.5%)

1 (3.2%)

Median boost volume in ccm (IQR)

14.8 (7.8–72.9)

16.6 (8.8–78.2)

0.2 (n = 1)

Median boost EQD2₂ in Gy (IQR)

69.3 (67.7–71.7)

69.3 (66.8–71.1)

90.6 (n = 1)

Prescription isodose line

 70%

 80%

 95%

11 (20.8%)

16 (30.2%)

26 (49.1%)

1 (4.5%)

1 (4.5%)

20 (90.9%)

10 (32.3%)

15 (48.4%)

6 (19.4%)