Table 1 Patient and RID lesion characteristics
All lesions | High-grade glioma | Brain metastasis | |
|---|---|---|---|
Number of patients | 33 | 18 (55.5%) • Glioblastoma WHO grade 4: 11 (61.1%) • Oligodendroglioma WHO grade 3: 4 (22.2%) • Astrocytoma WHO grade 3: 3 (16.7%) | 15 (45.5%) • Non-small cell lung cancer: 5 (33.3%) • Malignant melanoma: 3 (20.0%) • Renal cell carcinoma: 2 (13.3%) • Breast cancer: 2 (13.3%) • Colorectal cancer: 1 (6.7%) • Thyroid carcinoma: 1 (6.7%) • Adenocarcinoma of the esophagogastric junction: 1 (6.7%) |
Median age in years at resection of first RID lesion (IQR) | 56.0 (49.0–64.5) | 55.5 (47.8–65.0) | 56.0 (50.0–64.0) |
Gender | |||
Female | 16 (48.5%) | 10 (55.6%) | 6 (40.0%) |
Male | 17 (51.5%) | 8 (44.4%) | 9 (60.0%) |
Median time-to-RID (interval between last RT and first occurrence of RID in MRI) in months (range) | 5.8 (0.7–29.0) | 5.6 (0.7–29.0) | 5.8 (2.3–23.7) |
Number of RID lesions | 34 | 18 (52.9%) | 16 (47.1%) |
RID pathology | |||
RID | 24 (70.6%) | 10 (55.6%) | 14 (87.5%) |
RID + single tumor cells | 10 (29.4%) | 8 (44.4%) | 2 (12.5%) |
Type of surgery | |||
Resection | 30 (88.2%) | 15 (83.3%) | 15 (93.8%) |
Biopsy | 3 (8.8%) | 3 (16.7%) | 0 (0.0%) |
Autopsy | 1 (2.9%) | 0 (0.0%) | 1 (6.3%) |
Reasons for histopathological confirmationa | |||
Suspected tumor recurrence or progression or ambiguous resultsb of the obtained imaging + symptoms associated with the lesion | 21 (63.6%) | 10 (58.8%) | 11 (68.8%) |
Suspected tumor recurrence or progression or ambiguous resultsb of the obtained imaging without any symptoms associated with the lesion | 10 (30.3%) | 7 (41.2%) | 3 (18.8%) |
Suspected RID based on the obtained imaging, resection because of symptoms | 1 (3.0%) | 0 (0.0%) | 1 (6.3%) |
Autopsy / death of patient | 1 (3.0%) | 0 (0.0%) | 1 (6.3%) |
Data not available | 1 | 1 | 0 |