OARs | Characteristics | Ling et al. (50.4Â Gy) [9] | Takakusagi et al. (50.4Â Gy) [35] | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Proton | IMRT | p | 3DCRT | p | Carbon | VMAT | p | 3DCRT | p | ||
Spinal cord | Dmax (Gy) | 11.6 ± 10.0 | 36.9 ± 3.5 | 0.001 | 31.2 ± 9.7 | 0.001 | 25.6 ± 3.5 | 41.3 ± 2.9 | < 0.001 | 44.6 ± 0.6 | < 0.001 |
Lungs | Dmean (Gy) | 6.0 ± 2.6 | 9.5 ± 3.2 | 0.016 | 9.4 ± 4.0 | 0.040 | 1.8 ± 0.9 | 11.4 ± 2.3 | < 0.001 | 5.3 ± 1.8 | < 0.001 |
V5 (%) | 21.4 ± 10.3 | 46.9 ± 17.6 | 0.001 | 34.1 ± 13.9 | 0.032 | 8.4 ± 3.7 | 77.7 ± 17.8 | < 0.001 | 21.6 ± 8.3 | < 0.001 | |
V10 (%) | 19.4 ± 8.6 | 37.8 ± 14.7 | 0.003 | 29.1 ± 12.7 | 0.060 | 6.7 ± 3.2 | 52.5 ± 12.1 | < 0.001 | 14.8 ± 5.5 | < 0.001 | |
V20 (%) | 15.3 ± 6.5 | 16.2 ± 5.8 | 0.794 | 22.1 ± 10.8 | 0.114 | 2.6 ± 1.7 | 14.8 ± 5.5 | < 0.001 | 7.7 ± 3.3 | < 0.001 | |
V30 (%) | 6.1 ± 2.9 | 6.6 ± 3.2 | 0.720 | 9.8 ± 5.1 | 0.067 | 1.4 ± 1.0 | 3.9 ± 2.3 | < 0.001 | 5.5 ± 2.5 | < 0.001 | |
V40 (%) | 4.3 ± 2.1 | 3.5 ± 2.0 | 0.391 | 4.7 ± 2.9 | 0.682 | 0.3 ± 0.5 | 1.0 ± 0.9 | 0.001 | 2.2 ± 1.2 | < 0.001 | |
V50 (%) | 1.1 ± 1.0 | 1.6 ± 1.3 | 0.251 | 3.3 ± 2.1 | 0.008 | 0.0 ± 0.1 | 0.0 ± 0.1 | 0.157 | 0.1 ± 0.2 | 0.006 | |
Heart | Dmean (Gy) | 12.6 ± 3.9 | 28.5 ± 5.5 | 0.001 | 27.5 ± 5.2 | 0.001 | 9.6 ± 4.5 | 22.3 ± 9.0 | < 0.001 | 29.1 ± 11.7 | < 0.001 |
V10 (%) | N/A | N/A | N/A | N/A | N/A | 46.5 ± 21.0 | 99.6 ± 39.6 | < 0.001 | 69.2 ± 28.1 | < 0.001 | |
V20 (%) | N/A | N/A | N/A | N/A | N/A | 9.8 ± 5.6 | 45.0 ± 24.1 | < 0.001 | 61.4 ± 25.8 | < 0.001 | |
V30 (%) | 20.9 ± 7.1 | 42.3 ± 15.3 | 0.001 | 32.7 ± 9.4 | 0.005 | 6.7 ± 3.7 | 18.0 ± 9.6 | < 0.001 | 57.3 ± 24.8 | < 0.001 | |
V40 (%) | 16.2 ± 6.4 | 25.5 ± 11.0 | 0.036 | 25.8 ± 8.8 | 0.012 | 4.8 ± 2.6 | 7.3 ± 5.0 | < 0.001 | 51.1 ± 23.5 | 0.001 | |
V50 (%) | 2.8 ± 2.3 | 12.0 ± 8.6 | 0.008 | 20.0 ± 12.6 | 0.002 | 0.9 ± 0.6 | 1.1 ± 1.0 | 0.068 | 8.3 ± 6.6 | 0.006 |