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Table 3 Multivariable Logistic regression analysis of factors related to lymphocyte unrecovered from radiation-induced lymphopenia

From: Lymphocyte recovery from radiation-induced lymphopenia in locally advanced esophageal squamous cell carcinoma: correlations with prognosis and lymphocyte-related organs

 

Group A versus Group B

 

Group C versus Group D

OR (95% Cl)

p

OR (95% Cl)

p

Tumor stage*

 

0.072

Tumor stage*

 

0.023

 II

0.14 (0.02–1.20)

 

 II

0.39 (0.17–0.88)

 

 III + IV

Ref

 

 III + IV

Ref

 

Consolidation chemo cycles

 

0.421

Consolidation chemo cycles

–

–

 2 cycles

1.70 (0.47–6.16)

 

 2 cycles

  

 0–1 cycle

Ref

 

 0–1 cycle

  

Bone marrow V5

 

0.027

Bone Marrow V5

 

0.025

 ≥ 40.7%

4.24 (1.18–15.20)

 

  ≥ 46.0%

2.29 (1.11–4.73)

 

 < 40.7%

Ref

 

  < 46.0%

Ref

 

EDIC

–

–

EDIC

 

0.460

 ≥ 11.8 Gy

  

  ≥ 10.3 Gy

1.32 (0.63–2.78)

 

 < 11.8 Gy

  

  < 10. 3 Gy

Ref

 
  1. ALC: absolute lymphocyte count; dCCRT: definitive concurrent chemoradiotherapy; EDIC, the effective dose to immune cells; LRI, lymphocyte recovery index
  2. *According to AJCC 6th. Group A included patients with G4 ALC nadir during dCCRT and LRI < 60% (N = 27); group B with G4 ALC nadir during dCCRT and LRI ≥ 60% (N = 42); group C included patients with G1–3 ALC nadir during dCCRT and LRI < 60% (N = 67) and group D with G1–3 ALC nadir during dCCRT and LRI ≥ 60% (N = 96)