Skip to main content

Table 6 Dosimetric analysis of organs at risk for the re-irradiation SABR group

From: Treatment outcomes of re-irradiation using stereotactic ablative radiotherapy to lung: a propensity score matching analysis

Organs

Parameters

Cumulative EQD2 (Gy, median, range)

Univariate analysis with grade ≥ 2  toxicity

OR

95% CI

P value

Lung (unilateral)

Mean dose

20.19 (5.16–38.88)

0.859

0.724–1.019

0.081

V20 (%)

26.79% (5.75–68.25%)

0.918

0.824–1.021

0.116

Lung (bilateral)

Mean dose

11.88 (2.50–20.73)

0.824

0.638–1.064

0.138

V20 (%)

11.67% (2.59–32.52%)

0.894

0.762–1.049

0.171

Proximal bronchial tree

D0.5 cc

53.86 (0.39–124.57)

0.980

0.948–1.014

0.244

D1cc

46.88 (0.35–84.57)

0.969

0.931–1.009

0.128

D5cc

17.87 (0.28–79.20)

0.950

0.892–1.011

0.109

D10cc

11.55 (0.24–73.74)

0.931

0.831–1.043

0.219

D15cc

8.56 (0.19–69.84)

0.924

0.797–1.072

0.297

D30cc

1.26 (0.11–64.57)

0.468

0.098–2.228

0.340

Chest wall

D0.5 cc

199.45 (142.05–357.78)

1.024

0.998–1.051

0.066

D1cc

179.44 (119.39–335.21)

1.024

0.997–1.050

0.077

D5cc

131.28 (42.74–261.98)

1.021

0.995–1.047

0.114

D10cc

110.07 (17.33–220.61)

1.024

0.995–1.055

0.110

D15cc

97.22 (13.41–198.90)

1.028

0.994–1.063

0.103

D30cc

75.64 (9.16–162.43)

1.033

0.994–1.074

0.096

Aorta

D0.5 cc

32.63 (6.96–233.03)

D1cc

30.40 (6.45–195.23)

D5cc

24.30 (5.19–99.37)

D10cc

20.69 (4.69–69.04)

D15cc

18.10 (4.18–66.20)

D30cc

12.30 (1.54–59.15)

Esophagus

D0.5 cc

18.25 (6.20–63.97)

D1cc

17.09 (5.70–61.28)

D5cc

12.22 (1.56–50.37)

D10cc

2.85 (0.32–27.04)

D15cc

0.89 (0.21–18.61)

Heart

D0.5 cc

32.80 (0.20–93.95)

D1cc

30.71 (0.20–90.38)

D5cc

23.27 (0.19–79.56)

D10cc

19.14 (0.17–71.93)

D15cc

16.69 (0.16–70.19)

D30cc

12.58 (0.15–67.12)

  1. Calculated with grade ≥ 2 pulmonary toxicity (cough, dyspnea)
  2. Calculated with grade ≥ 2 chest wall pain
  3. EQD2, dose delivered in 2 Gy fractions; OR, odds ratio; CI, confidence interval