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Table 1 Summary of the detectors currently available [5, 16,17,18,19]

From: Preclinical dosimetry: exploring the use of small animal phantoms

Detector

Specifications

Advantages

Disadvantages

Ionisation chambers

• Commissioning

• Dose calibration

• QA

• Uncertainty: < 5%

• Dose: up to 1000Gy

• High precision and accuracy

• Various models, including waterproof models

• No effect from dose rate

• Instant readout

• Requires high voltage

• Size

• Elaborate care

Radio-graphic Film

• Imaging

• Dosimetry

• Phantom compatible

• Uncertainty: < 5%

• Dose: 0.1-5Gy

• Great spatial resolution

• 2D dose distribution

• No effect from dose rate

• Various film types

• Useful for assessing field size, flatness and symmetry

• Complex processing

• Film type/batch variation

• Dose calibration required

• Affected by energy

• Light sensitive

• Not reusable

Radio-chromic Film

• Imaging

• 2D Dosimetry

• Phantom compatible

• Uncertainty: < 5%

• Dose: 0.1-200Gy

• Self-processing

• Tissue-equivalent

• No effect from dose rate/energy

• Great spatial resolution

• Useful for radiation field size, flatness and symmetry

• Results vary between film types and batches

• Dose calibration required

• Not reusable

• Requires stabilisation period after irradiation

TLDs

• In vivo dosimetry

• Phantom compatible

• Audit purposes

• Uncertainty: < 5%

• Dose:<200Gy

• Small size

• Multiple point readings

• Various models available

• Reusable

• Laborious calibration

• Delayed results

• Signal erased during readout

• Results vary between batch

• Light sensitive

OSLDs

• In vivo dosimetry

• Phantom compatible

• Audit purposes

• Uncertainty: < 4%

• Dose: <10Gy

• Moderate size

• Multiple point readings

• Quick readout

• No effect from dose rate

• Light sensitive

• Limited availability

• Not suitable for calibration

• Energy dependent

Silicon Diodes

• In vivo dosimetry

• Detector arrays

• Dosimetry

• Uncertainty: < 3%

• Dose: <10Gy

• Moderate size

• Instant readout

• Good sensitivity

• No external voltage

• Small field dosimetry

• Requires connecting cables

• Temperature sensitive

• Unsuitable for calibration

• Unsuitable at higher doses

MOSFETs

• In vivo dosimetry

• Small field dosimetry

• Detector arrays

• Uncertainty: < 5%

• Dose: <10Gy

• Small size (0.2 × 0.2 mm)

• Multiple point readings

• quick readout

• Good sensitivity

• Calibration required

• Energy, temperature and directional dependent

• Unsuitable for calibration

Diamond Detectors

• In vivo and small field dosimetry

• Uncertainty: < 3%

• Dose: <10Gy

• Small size

• Tissue-equivalent

• High sensitivity

• Resistant to radiation

• External equipment required

• Requires pre-irradiation

• Results vary among detectors

• Unsuitable for calibration

Alanine – Electron para-magnetic resonance

• In vivo dosimetry

• Phantom compatible

• Audit purposes

• Uncertainty: < 4%

• Dose: 10-150000Gy

• Tissue-equivalent

• Readout process does not diminish signal

• Readout requires specific equipment

Gel dosimetry detectors

• 3D dosimetry

• Audit purposes

• Uncertainty: 5–10%

• Dose: <10Gy

• Tissue-equivalent

• Both phantom and detector

• 3D dose distribution

• Elaborate preparation

• Continued processing

• Difficult reproducibility

• Unsuitable for calibration

  1. Key: QA quality assurance, TLDs thermoluminescent detectors, OSLDs optically-stimulated luminescent detectors, MOSFETs metal oxide semiconductor field effect transistors