Table 2 Selected published studies on radiotherapy or chemotherapy in older patients with high.grade gliomas/glioblastomas
From: Radiation therapy for older patients with brain tumors
Authors | Type of study | Patients | Age years | RT dose Gy/fractions | CHT | Median PFS months | Median OS months |
|---|---|---|---|---|---|---|---|
Bauman GS et al. [45] | Prospective | 29 | ≥65 | 30/10 | no | NA | 6 |
Ford JM et al. [46] | Prospective | 27 | ≥60 | 36/12 | no | NA | 4 (11% at 1 year) |
Hoegler DB et al. [47] | Prospective | 25a | ≥70 | 37.5/15 | no | NA | 8 |
McAleese JJ et al. [48] | Prospective | 30 29 | 65-70 ≥ 70 | 30/6 30/6 | no no | NA NA | 37% at 6 months 41% at 6 months |
Chinot O et al. [49] | Prospective | 32 | ≥70 | no | TMZ° | 5 (15% at 1 year) | 6.4 (25% at 1 years) |
Roa W et al. [50] | Randomized | 51 49 | ≥60 ≥ 60 | 60/30 40/15 | no no | NA NA | 5.1 5.6 |
Keime-Guiber F et al. [44] | Randomized | 39 39 | ≥70 ≥ 70 | 50/28 no | no no | 3.6 1.5 | 7 4 |
Gallego Perez-Larraya et al. [51] | Prospective | 70 | ≥70 | no | TMZ° | 4 (6.5% at at 1 year) | 6 (11.4% at 1 year) |
Malmstrom et al. [52] | Randomized | 100 98 93 | >60 > 60 | 60/30 34/10 no | no no TMZ° | NA NA NA | 6 (17% at 1 year) 7.5 (23% at 1 year) 8.3 (27% at 1 year) |
Wick et al. [53] | Randomized | 178a 195a | >65 > 65 | 60/30 no | no TMZ °° | 4.7 (9.3% at 1 year) 3.3 (12% at 1 year) | 9.6 (37.4% at 1 year) 8.6 (34.4% at 1 year) |
Roa et al. [54] | Randomized | 48a 50a | ≥65 ≥ 65 | 40/15 25/5 | no no | 4.2 4.2 | 7.9 6.4 |