Intraoperative radiation therapy for colon and rectal cancers: a clinical review

Radiation Oncology

Table 4 Disease control and survival with IORT for locally recurrent rectal cancer in association with R1 resection. Results of selected series

Study	Years	# Patients	EBRT dose, Gy	IORT dose, Gy	IORT technique	5-year LC	5-year DM	5-year OS
Alektiar, MSKCC [30]	1992–1998	21	50.4^a	10–18	IOHDR	26%	-	11%
Wiig, Norway [33]	1990–1999	29	46–50	15–20	IOERT	50%	-	20%
Eble, Heidelberg [33]^b	1991–1995	9	41.4	10–20	IOERT	67%	33%	33%^c
Dresen, Eindhoven [34]^f	1994–2006	34	50.4^d	12.5	IOERT	29%	69%	27%
Haddock, Mayo Clinic [19]	1981–2008	224	50.4^e	15	IOERT	56%	62%	27%

Abbreviations: R1 microscopic residual disease, EBRT external beam radiation therapy, IORT intraoperative radiation therapy, LC local control, DM distant metastases, OS overall survival, MSKCC Memorial Sloan Kettering Cancer Center, IOHDR intraoperative high dose rate brachytherapy
^a50.4 in patients with no prior EBRT; no EBRT in patients with prior radiation
^b4-year results
^c4-year relapse free survival
^d30.6 Gy in previously irradiated patients
^e5–39.6 Gy in previously irradiated patients
^f3-year results

ISSN: 1748-717X