Fig. 3From: Biology of high single doses of IORT: RBE, 5 R’s, and other biological aspectsProposed schematic model of increasing use of alternative end joining (alt-EJ) leading to increased chromosomal instability at higher doses. HR: homologous recombination. NHEJ: non-homologous end joining. Modified after Shibata and Jeggo [30]Back to article page