ERCC2 polymorphisms and radiation-induced adverse effects on normal tissue: systematic review with meta-analysis and trial sequential analysis

Table 2 Summary of meta-analysis results for the association between ERCC2 polymorphisms and radiotoxicity

Variable	No. of cohorts	Cases/Total	OR [95 % CI]^a	P _z-test	I ² (%)	P _het	Power (%)
rs13181
Dominant model	9	342/1486	0.71 [0.55, 0.93]	0.01	0	0.59	79.2
Early adverse effect	8	325/1417	0.72 [0.55, 0.94]	0.02	0	0.49	73.8
Acute skin toxicity	4	219/895	0.85 [0.61, 1.20]	0.36	0	0.43	18.0
Acute esophageal toxicity	2	70/273	0.56 [0.32, 0.97]	0.04	0	0.49	54.6
Acute gastrointestinal toxicity	2	36/249	0.44 [0.19, 1.02]	0.06	0	0.87	52.7
Recessive model	5	286/1090	0.75 [0.50, 1.12]	0.16	43	0.14	27.4
Allelic model	5	286/1090	0.78 [0.64, 0.97]	0.02	27	0.24	68.5
rs1799793
Dominant model	5	256/1687	1.15 [0.86, 1.53]	0.34	0	0.41	16.9
Early adverse effect	4	130/1287	1.36 [0.96, 1.92]	0.09	0	0.75	35.2
Acute skin toxicity	2	84/529	1.48 [0.97, 2.26]	0.07	0	0.42	31.9
Recessive model	3	236/1540	0.67 [0.41, 1.08]	0.10	0	0.49	38.9
Allelic model	3	236/1540	0.99 [0.80, 1.23]	0.95	44	0.17	5.1
rs1052555
Dominant model	2	46/758	0.98 [0.53, 1.80]	0.95	0	0.74	5.1

ISSN: 1748-717X