Table 4 Univariate and multivariable Cox proportional hazards analysis for distant failure

Age (continuous)

1.00 (0.98-1.02)

0.872

Age (>70 or ≤ 70)^a

1.10 (0.59-2.07)

0.760

Gender (female or male)

0.89 (0.52-1.53)

0.675

KPS (>80 or ≤ 80)

3.20 (1.21-8.48)

0.019

4.37 (1.58-12.06)

0.004

Extracranial disease (absent vs. stable/active)

2.63 (1.04-6.68)

0.041

2.60 (1.29-5.27)

0.008

Extracranial disease (absent/stable vs. active)

2.58 (1.33-5.01)

0.005

No. of lesions

  1

1.00

  2-3

3.13 (1.48-6.61)

0.003

2.30 (1.08-4.91)

0.032

  >3

5.93 (2.65-13.26)

<.0001

5.27 (2.40-11.57)

<.0001

BRAF (WT vs. mutation)

0.89 (0.49-1.63)

0.713

Metastases volume (<1 cc vs. ≥1 cc)

1.47 (0.85-2.54)

0.171

Treatment volume (<4 cc vs. ≥4 cc)

1.70 (0.99-2.92)

0.054

Peri-SRS systemic therapy (no vs. yes)

1.48 (0.87-2.54)

0.150

Post-SRS systemic therapy (no vs. yes)

0.74 (0.29-1.89)

0.534