Table 3 Univariate analysis of volumetric parameter cut-off values compared to survival outcomes

Sex

Male

137

41.6

0.251

22.9

0.589

36.6

0.017

Female

20

63.3

23.8

55.0

Age

≤ 60 y

65

41.3

0.563

20.5

0.444

35.5

0.307

> 60 y

92

47.9

25.0

37.1

ECOG

0

39

32.6

0.611

15.0

0.318

34.4

0.721

1-2

118

47.8

25.5

36.8

Histology

SqCC

86

36.0

0.048

24.0

0.517

32.0

0.151

Others

71

56.3

19.2

41.8

ADC

52

52.5

0.110

19.2

0.596

45.0

0.335

Others

105

40.5

24.9

34.6

T stage

1-2

79

56.4

0.034

25.2

0.281

43.8

0.106

3-4

78

33.8

20.7

28.7

N stage

0-2

81

49.4

0.448

29.2

0.108

37.0

0.686

3

76

39.5

17.0

35.6

Stage

IIIA

49

56.5

0.084

33.1

0.041

42.0

0.705

IIIB

108

39.8

18.6

33.7

GTV_pre

(Continuous)

(95% CI)

(1.001)

(0.330)

(1.003)

(<0.001)

(1.001)

(0.019)

(HR)

(0.999–1.002)

(1.002–1.004)

(1.000–1.002)

≤ 50 cm³

33

75.0

0.001

42.5

0.001

65.7

< 0.001

> 50 cm³

124

34.8

17.1

28.4

GTV_post

(Continuous)

(95% CI)

(1.004)

(0.189)

(1.015)

(<0.001)

(1.006)

(0.008)

(HR)

(0.998–1.010)

(1.008–1.021)

(1.002–1.011)

≤ 20 cm³

68

53.3

0.165

32.4

0.004

43.2

0.015

> 20 cm³

89

36.7

15.5

31.0

VRR

(Continuous)

(95% CI)

(1.011)

(0.126)

(1.008)

(0.139)

(1.013)

(0.028)

(HR)

(0.997–1.025)

(0.997–1.020)

(1.001–1.025)

≤ 50%

21

68.2

0.042

39.6

0.054

64.6

0.004

>50%

136

40.6

20.2

32.2