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Table 1 Univariate analysis of risk factors of osteoradionecrosis

From: Effects of the dose-volume relationship on and risk factors for maxillary osteoradionecrosis after carbon ion radiotherapy

Factors

Subgroup

n

p value

5-y ORN rate (%)

V10

<14.5 ml

31

 

26.1

 

≥14.5 ml

32

0.015

53

V20

<11.9 ml

31

 

20

 

≥11.9 ml

32

0.001

58.5

V30

<8.1 ml

31

 

13.7

 

≥8.1 ml

32

0.001

64.4

V40

<4.6 ml

31

 

12.1

 

≥4.6 ml

32

0.0002

67.7

V50

<3.0 ml

31

 

11.7

 

≥3.0 ml

32

0.0002

69.5

Age (years)

<59

31

 

33.5

 

≥59

32

0.23

45.5

Sex

Male

31

 

40.4

 

Female

32

0.5

38.2

Teeth in the PTV

None

34

 

5.9

 

Some

29

0.0001

81

Smoking

Yes

22

 

41.6

 

No

41

0.66

38.6

Alcohol

Yes

31

 

48.6

 

No

32

0.11

30.3

Chemotherapy

Yes

23

 

54.0

 

No

40

0.04

30.5

  1. A large V10 to V50 and the presence of teeth within the PTV were found to correlate with ORN development.