Figure 2

sHsp70 serum levels in blood of patients with SCCHN. A. sHsp70 concentrations in sera of patients (n = 21) before therapy compared to healthy donors (n = 28). B. sHsp70 serum data from patients were separated into two groups (high n = 11, low n = 10) reflecting the mHsp70 membrane expression as measured in A. C. Standard box plots are shown with boundaries indicating the 25^th and the 75^th percentile. The line inside boxes indicates the median and the whiskers indicate the 10^th and 90^th percentile, respectively. All outliers are shown. (***p < 0.001) C. ROC curve of data from (A) were attained by SigmaPlot software showing an AUC of 0.9101 (p < 0.0001, CI 95%). The cut-off level was 2.5 ng/ml with a sensitivity of 89% and a specificity of 91%). Abbr.: ROC, receiver operating characteristic; AUC, area under the curve; CI, confidence interval.