64Cu-ATSM and 18FDG PET uptake and 64Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry

Table 2 FDG and ⁶⁴ Cu-ATSM PET uptake vs. Pimonidazole staining

	Maximum pimonidazole labeled pixel value	Mean pimonidazole positive area fraction
⁶⁴Cu-ATSM T_max/M_mean 3 h.	0.81 (p = 0.011)	0.69 (p = 0.043)
⁶⁴Cu-ATSM T_mean/M_mean 3 h.	0.77 (p = 0.021)	0.56 (p = 0.126)
⁶⁴Cu-ATSM T_max/M_mean 24 h.	0.40 (p = 0.396)	0.036 (p = 0.964)
⁶⁴Cu-ATSM T_mean/M_mean 24 h.	0.70 (p = 0.088)	0.24 (p = 0.595)
¹⁸FDG SUV_max	0.82 (p = 0.008)	0.79 (p = 0.014)
¹⁸FDG SUV_mean	0.85 (p = 0.008)	0.77 (p = 0.017)

Pimonidazole maximum labeled pixel value and mean pimonidazole positive area fraction of individual tumors correlated to their ⁶⁴Cu-ATSM maximum and mean T/M ratios 3 and 24 h. pi. and ¹⁸FDG maximum and mean SUV. Spearman non-parametric correlation coefficients and p-value. Significant correlations in bold.

ISSN: 1748-717X